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Shin Yee Fung

Country of origin: Malaysia Currently in: Malaysia, Kuala Lumpur General field of specialization: Medical and Health Sciences incl Neurosciences
Academic Background

Degrees

2008 Doctorate Medical and Health Sciences incl Neurosciences
2002 Master Medical and Health Sciences incl Neurosciences
1999 Undergraduate Chemical Sciences
Research and Profession

Current Research Activities

Medical and Health Sciences incl Neurosciences

Medicinal Mushrooms Biomedical Applications of Natural Products Drugs Discovery


Publications resulting from Research: 


Chapter in Book

2021
Shin Yee Fung and Chon-Seng Tan (2021). Mushroom Market in Malaysia. In Kandikere R. Sridhar, Sunil K. Deshmukh (Eds), Advances in Macrofungi Industrial Avenues and Prospects, CRC Press

Razif, MFM., & Fung, SY., (2021). Cosmeceuticals From Mushrooms. In K.R Sridhar and S.K. Deshmukh (Eds), Advances in Macrofungi: Pharmaceuticals and Cosmeceuticals (pp 232-255), CRC Press

Shin Yee Fung and Muhammad Fazril Razif (2021). Bioprospecting macrofungi for biotechnological and biomedical applications. In Kandikere R. Sridhar, Sunil K. Deshmukh (Eds), Advances in Macrofungi Industrial Avenues and Prospects, CRC Press, 374 Pages


2019

Shin Yee FUNG & Chon Seng TAN, Tiger Milk Mushroom (The Lignosus Trinity) in Malaysia: A Medicinal Treasure Trove. In D.C.Agrawal & M. Dhanasekaran (Eds), Medicinal Mushrooms: Recent Progress in Research and Development (pp. 349-370). Springer Nature.

Shin Yee Fung and Muhammad Fazril Mohamad Razif (2019) . Proteomics of Edible and Medicinal Mushrooms. In K.R. Sridhar & S.K. Deshmukh (Eds), Advances in Macrofungi: Diversity, Ecology, and Biotechnology (ISBN 9781138587274) CRC Press

2018

Cheong, Peter Chiew Hing, Tan, Chon Seng & Fung, Shin Yee (2018). Application of Wild Macrofungi as Anticancer Therapeutics. In Bhim Pratap Singh, Lallawmsanga Chhakchhauk, Ajit Kumar Passari (Eds), Biology of Macrofungi (Series: Fungal Biology), Springer International Publishing AG, Gewerbestrasse 11, 6330 Cham, Switzerland

Cheong, Peter Chiew Hing, Tan, Chon Seng & Fung, Shin Yee (2018). Medicinal Mushrooms: Cultivation and pharmaceutical impact. In Bhim Pratap Singh, Lallawmsanga Chhakchhauk, Ajit Kumar Passari (Eds), Biology of Macrofungi (Series: Fungal Biology), Springer International Publishing AG, Gewerbestrasse 11, 6330 Cham, Switzerland

2017

Fung, S.Y., & Tan, C.S. (2017). The Bioactivity of Tiger Milk Mushroom : Malaysia's Prized Medicinal Mushroom. In Agrawal, D.C., Tsay, H.-S., Shyur, L.-F., Wu, Y.-C., Wang, S.-Y. (Eds.) , Medicinal Plants and Fungi: Recent Advances in Research and Development (pp. 111-134). Springer Nature Singapore.

2015

Tan, N.H., Fry, B.G., Sunagar, K. , Jackson, T.N.W., Reeks, T. and Fung, S.Y. (2014). Chapter 16: L-Amino Acid Oxidase: Enzymes. In: Fry B.G. ed. Venomous Reptiles And Their Toxins: Evolution, Pathophysiolgy and Biodiversity. 2014, Oxford University Press

Shin Yee Fung and Nget Hong Tan (2015) Chapter 11: Fungal as a source of antitumor agent. In: "Fungal Biomolecules [Eds. Drs. V.K. Gupta (NUIG, Ireland), S. Sreenivasaprasad (University of Bedfordshire, UK) and R. Mach (TU, Vienna)], Wiley- Blackwell, England, pp 145-152

2011

Tan, N.H., Fung, S.Y., Sim, S.M. (2011) Extracts of Cowhage (Mucuna Pruriens) Seeds and Anti-snake Venom Effects. In: Preedy VR, Watson, R.R. and Patel VB (Editors), Nuts and Seeds in Health and Disease Prevention (1st ed). Chapter 48, 401-408, London, Burlington, San Diego: Academic Press is an imprint of Elsevier, USA. ISBN: 9780123756886

2009

Nget-Hong, Tan & Shin-Yee Fung 2009, Snake venom L- amino acid oxidases. In: Handbook of Venoms and Toxins of Reptiles, Taylor and Francis/CRC Press

Article in Academic Journals

2021
Jian Yi Chai, Vaisnevee Sugumar, Won Fen Wong, Ahmed F. Alshanon, Shin Yee Fung , Chung Yeng Looi (2021) Defining the role of GLI/Hedgehog signaling in chemoresistance: Implications in therapeutic approaches, Cancers (ISI-Indexed)

Boon-Hong Kong, Chee-Sum Alvin Yap, Muhammad Fazril Mohamad Razif, Szu-Ting Ng, Chon-Seng Tan, Shin-Yee Fung (2021). The Antioxidant and Cytotoxic Effects of Ophiocordyceps sinensis and Identification of Bioactive Proteins Using Shotgun Proteomic Analysis, Food Technology and Biotechnology, 59(2) (ISI-Indexed)

Boon-Hong Kong & Shin-Yee Fung (2021) Longitudinal Assessment of Lignosus rhinocerus sclerotium cultivar: The uniformity of bioactive components, International journal of medicinal mushrooms

Soon Hong Kwan Wan Izlina Wan Ibrahim Thaneswari Juvarajah Shin Yee Fung Puteri Shafinaz Abdul Rahman (2021). Isolation and identification of O- and N-linked glycoproteins in milk from different mammalian species and their roles in biological pathways which support infant growth. Electrophoresis, doi.org/10.1002/elps.202000142 (ISI-Indexed)

2020

Alvin Yap Chee Sum, Xiaojie Li, Yeannie Yap Hui Yeng, Muhammad Fazril Mohamad Razif, Amira Hajirah Abd Jamil, Ng Szu Ting, Tan Chon Seng, Peter Chi Keung Cheung, Shin-Yee Fung (2020) The Immunomodulating Properties of Lignosus rhinocerus TM02 Cultivar and Its Associated Carbohydrate Composition, International Journal of Medicinal Mushroom 10.1615/IntJMedMushrooms.2020035658 (ISI-Indexed)

Alvin Yap Chee Sum, Xiaojie Li, Yeannie Yap Hui Yeng, Muhammad Fazril Mohamad Razif, Amira Hajirah Abd Jamil, Ng Szu Ting, Tan Chon Seng, Cheung Chi Keung Peter, Fung Shin Yee (2020). Immunomodulatory properties of water-soluble polysaccharides extracted from the fruiting body of Ophiocordyceps sinensis cultivar OCS02 , International Journal of Medicinal Mushrooms (ISI-Indexed)

Boon Hong Kong, Kean Hooi Teoh, Nget Hong Tan, Chon Seng Tan, Szu Ting Ng, Shin Yee Fung (2020). Proteins from Lignosus tigris with selective apoptotic cytotoxicity towards MCF7 cell line and suppresses MCF7-xenograft tumor growth. Peer J (ISI-Indexed)

2019

Peter Chiew Hing Cheong, Yen Sun Yong, Ayesha Fatima, Szu Ting Ng, Chon Seng Tan, Boon Hong Kong, Nget Hong Tan, Jayakumar Rajarajeswaran & Shin Yee Fung (2018). Cloning, overexpression, purification, and modeling of a lectin (Rhinocelectin) with antiproliferative activity from Tiger Milk Mushroom, Lignosus rhinocerus. IUBMB Life. 2019;71: 1579–1594. https://doi.org/10.1002/iub.2101 (ISI-Indexed)

Shin Yee Fung, Peter Chiew Hing Cheong, Nget Hong Tan, Szu Ting Ng, Chon Seng Tan (2019) Nutritional evaluation on Lignosus cameronensis C. S. Tan, a medicinal Polyporaceae, IUBMB Life 1-6 (ISI-Indexed)

Esther Lai Har Tang, Nget Hong Tan, Shin Yee Fung, Choo Hock Tan (2019). Comparative proteomes, immunoreactivities and neutralization of procoagulant activities of Calloselasma rhodostoma (Malayan pit viper) venoms from four regions in Southeast Asia. Toxicon. (ISI-Indexed)

2018

Thaneswari Juvarajah, Wan Izlina Wan-Ibrahim, Ali Ashrafzadeh, , Shatrah Othman, Onn Haji Hashim, Shin Yee Fung and Puteri Shafinaz Abdul-Rahman (2018) Human milk fat globule membrane contains hundreds of abundantly expressed and nutritionally beneficial proteins that are generally lacking in that of caprine milk, Breastfeeding Medicine 2018 Nov;13(9):631-637. doi: 10.1089/bfm.2018.0057. (ISI-Indexed)

Hui Yeng Y Yap, Nget Hong Tan, Szu Ting Ng, Chon Seng Tan, Shin Yee Fung* (2018). Molecular attributes and apoptosis-inducing activities of a putative serine protease isolated from Tiger Milk mushroom (Lignosus rhinocerus) sclerotium against breast cancer cells in vitro, PeerJ 6:e4940 https://doi.org/10.7717/peerj.4940 (ISI-Indexed)

Shin Yee Fung, Peter Chiew Hing Cheong, Nget Hong Tan, Szu Ting Ng, Chon Seng Tan (2018). Nutrient and chemical analysis of the fruiting body of a cultivar of the Ophiocordyceps sinensis. International Journal of Medicinal Mushrooms. DOI: 10.1615/IntJMedMushrooms.2018026252 (ISI-Indexed)

Mei Kee Lee, Xiao Jie Li, Chee Sum Alvin Yap, Peter Chi Keung Cheung, Chon Seng Tan, Szu Ting Ng, Richard Roberts, Kang Nee Ting, Shin Yee Fung (2018). Airway relaxation effects of water-soluble sclerotial extract from Lignosus rhinocerotis , Frontiers in Pharmacology, section Ethnopharmacology 9:461. doi: 10.3389/fphar.2018.00461 (ISI-Indexed)

Shin-Yee Fung*, Mui-Li Lee & Nget-Hong Tan (2018). Proteomic investigation of the molecular mechanism of king cobra venom L-amino acid oxidase induced apoptosis of human breast cancer (MCF-7) cell line. Indian Journal of Experimental Biology,Vol. 56, February 2018, pp. 101-111 (ISI-Indexed)

Yap, YHY, Tan NH, Ng ST, Tan CS, Fung SY (2018). Inhibition of Protein Glycation by Tiger Milk Mushroom (Lignosus rhinocerus (Cooke) Ryvarden) and Search for Potential Anti-Diabetic Activity Related Metabolic Pathways by Genomic and Transcriptomic Data Mining. Frontier in Pharmacology: Section Ethnopharmacology.9:103. doi: 10.3389/fphar.2018.00103 (ISI-Indexed)

2017

Shin Yee Fung, Nget Hong Tan, Boon Hong Kong, Sook Shien Lee, Yee Shin Tan, Vikineswary Sabaratnam (2017). Acute Toxicity Study and the In Vitro Cytotoxicity of a Black Lingzhi Medicinal Mushroom, Amauroderma rugosum (Agaricomycetes) from Malaysia. International Journal of Medicinal Mushroom ( accepted for publication ) (ISI-Indexed)

Fung, S.Y., Lee, S.S., Tan, N.H., Pailoor, J. (2017). Safety assessment of cultivated fruiting body of Ophiocordyceps sinensis evaluated through subacute toxicity in rats. Journal of Ethnopharmacology 206:236-244 (ISI-Indexed)

Yap, H.Y.Y., Muria-Gonzalez, M.J., Kong, B.H., Stubbs, K.A., Tan, C.S., Ng, S.T., Tan, N.H., Solomon, P.S., Fung, S.Y., Chooi, Y.H. (2017).Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast. Microbial Cell Factories 16:103 (ISI-Indexed)

Shin Yee Fung, Sook Shien Lee, Nget Hong Tan, Jayalakhsmi Pailoor (2017). Safety evaluation of sclerotium from a medicinal mushroom, Lignosus cameronensis (cultivar): Preclinical toxicology studies, Frontiers in Pharmacology; 8: 594. doi: 10.3389/fphar.2017.00594 (ISI-Indexed)

2016

Esther Lai Har Tang , Choo Hock Tan , Shin Yee Fung , Nget Hong Tan (2016) Venomics of Calloselasma rhodostoma, the Malayan pit viper: A complex toxin arsenal unraveled, Journal of Proteomics ( accepted for publication ) (ISI-Indexed)

Vignesraaj Pushparajah, Ayesha Fatima, Chin Hung Chong, Thandeka Z Gambule, Chong Joo Chan, Szu Ting Ng, Chon Seng Tan, Shin Yee Fung, Sook Shien Lee, Nget Hong Tan, and Renee Lim (2016) Characterisation of a New Fungal Immunomodulatory protein from Tiger Milk mushroom, Lignosus rhinocerotis, NATURE Scientific Reports 6:30010 (ISI-Indexed)

Boon-Hong Kong, Nget-Hong Tan, Shin-Yee Fung,Jayalakshmi Pailoor, Chon-Seng Tan and Szu- Ting Ng. 2015. Nutritional composition, antioxidant properties and toxicology evaluation of the sclerotium of Tiger Milk Mushroom Lignosus tigris cultivar E, Nutrition Research 36: 174-183. (ISI-Indexed)

Kae Yi Tan, Choo Hock Tan, Si Mui Sim, Shin Yee Fung, Nget Hong Tan (2016) Geographical Venom Variations of the Southeast Asian Monocled Cobra (Naja kaouthia): Venom-Induced Neuromuscular Depression and Antivenom Neutralization. Comparative Biochemistry and Physiology Part C 185-186:77-86 (ISI-Indexed)

Shin Yee Fung; Choo Hock Tan; Michelle Khai Khun Yap; Poh Kuan Leong; Jia Lee Liew; Nget Hong Tan (2016) Unveiling the elusive and exotic: Venomics of the Malayan blue coral snake (Calliophis bivirgata flaviceps), Journal of Proteomics 132, 1-12 (ISI-Indexed)

Kae Yi Tan, Choo Hock Tan, Shin Yee Fung, Nget Hong Tan (2016) Neutralization of the principal toxins from the venoms of Thai Naja kaouthia and Malaysian Hydrophis schistosus: Insights into toxin-specific neutralization by two different antivenoms. Toxins 8:86 (ISI-Indexed)

Boon-Hong Kong, Nget-Hong Tan, Shin-Yee Fung,Jayalakshmi Pailoor, Chon-Seng Tan and Szu-Ting Ng (2016) Nutritional composition, antioxidant properties and toxicology evaluation of the sclerotium of Tiger Milk Mushroom Lignosus tigris cultivar E, Nutrition Research 174-183 (ISI-Indexed)

Shin Yee Fung, Boon Hong Kong, Nget Hong Tan, Jayalakshmi Pailoor (2016) Sub-acute Toxicity Study of Tiger Milk Mushroom Lignosus tigris Chon S. Tan Cultivar E Sclerotium in Sprague Dawley Rats, Frontiers in Pharmacology, section Ethnopharmacology 7:246 (ISI-Indexed)

2015

Kae Yi Tan, Choo Hock Tan, Shin Yee Fung, Nget Hong Tan (2015) Venomics, lethality and neutralization of Naja kaouthia (monocled cobra) venoms from three different geographical regions of Southeast Asia. Journal of Proteomics 120:105-125 (ISI-Indexed)

Choo Hock Tan, Kae Yi Tan, Shin Yee Fung and Nget Hong Tan (2015) Venom-gland transcriptome and venom proteome of the Malaysian king cobra (Ophiophagus hannah), BMC Genomics 16{1}:687 (ISI-Indexed)

Michelle Khai Khun Yap, Nget Hong Tan, Si Mui Sim, Shin Yee Fung, Choo Hock Tan (2015). The effect of polyvalent antivenom on the pharmacokinetics of Naja sputatrix (Javan spitting cobra) venom in experimentally envenomed rabbits, Basic & Clinical Pharmacology & Toxicology (accepted for publication) (ISI-Indexed)

Poh Kuan Leong, Shin Yee Fung, Choo Hock Tan, Si Mui Sim and Nget Hong Tan (2015) Immunological cross- reactivity and neutralization of the principal toxins of Naja sumatrana and related cobra venoms by a Thai polyvalent antivenom (Neuro Polyvalent Snake Antivenom)Acta Tropica 149:86-93 (ISI-Indexed)

Nget Hong Tan, Shin Yee Fung, Kae Yi Tan, Michelle Khai Khun Yap, Christeine Ariaranee Gnanathasan,Choo Hock Tan (2015) Functional venomics of the Sri Lankan Russell's viper (Daboia russelii) and its toxinological correlations. Journal of Proteomics 128: 403-423 (ISI-Indexed)

Shin Yee Fung, Mui Li Lee, Nget Hong Tan (2015) Molecular Mechanism Of Cell Death Induced By King Cobra (Ophiophagus hannah) Venom L-Amino Acid Oxidase, Toxicon 96:38-45 (ISI-Indexed)

Hui-Yeng Y. Yap, Shin-Yee Fung, Szu-Ting Ng, Chon-Seng Tan, Nget-Hong Tan (2015) Shotgun proteomic analysis of tiger milk mushroom (Lignosus rhinocerotis) and the isolation of a cytotoxic fungal serine protease from its sclerotium, Journal of Ethnopharmacology 174(2015)437 -451 (ISI-Indexed)

Hui-Yeng Y Yap, Yit-Heng Chooi, Shin-Yee Fung, Szu- Ting Ng, Chon-Seng Tan, Nget-Hong Tan (2015)Transcriptome Analysis Revealed Highly Expressed Genes Encoding Secondary Metabolite Pathways and Small Cysteine-Rich Proteins in the Sclerotium of Lignosus rhinocerotis, PLoS One http://dx.doi.org/10.1371/journal.pone.0143549 (ISI-Indexed)

Esther Lai-Har Tang, Jayakumar Rajarajeswaran, Shin Yee Fung, and M S Kanthimathi (2015)Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells, Journal of the Science of Food and Agriculture , DOI 10.1002/jsfa.7078 (ISI-Indexed)

Hui-Yeng Yeannie Yap, Shin-Yee Fung, Szu-Ting Ng, Chon-Seng Tan, Nget-Hong Tan (2015) Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium, International Journal of Medical Sciences 12(1):23-31 (ISI-Indexed)

Choo Hock Tan, Nget Hong Tan,Si Mui Sim, Shin Yee Fung, Christeine Ariaranee Gnanathasan (2015) Proteomic investigation of Sri Lankan hump-nosed pit viper (Hypnale hypnale) venom. Toxicon 93(164-170) (ISI-Indexed)

2014

Shin Yee Fung, Si Mui Sim, Kandiah Jeyaseelan, Arunmozhiarasi Armugam, John Chinyere Aguiyi & Nget Hong Tan (2014) Prophylatic effect of Mucuna pruriens Linn (velvet bean) seed extract against experimental Naja sputatrix envenomation: Gene expression studies, Indian Journal of Experimental Biology 52(9):849-59 (ISI-Indexed)

Yeannie H. Y. Yap, Shin-Yee Fung, Nget-Hong Tan, Szu- Ting Ng and Chon-Seng Tan (2013).DNA Barcode Markers for Two New Species of Tiger Milk Mushrooms: Lignosus tigris C. S. Tan and Lignosus cameronensis C. S. Tan, International Journal of Agriculture and Biology 16:841-844 (ISI-Indexed)

Sook Shien Lee, Nget Hong Tan, Shin Yee Fung, Si Mui Sim, Chon Seng Tan, Szu Ting Ng (2014) Anti- inflammatory effect of the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden, the Tiger Milk mushroom, BMC Complementary and Alternative Medicine 14:359 (8 pages) (ISI-Indexed)

Choo Hock Tan,Si Mui Sim, Christeine A Gnanathasan, Shin Yee Fung, Nget Hong Tan (2014) Pharmacokinetics of the Sri Lankan Hump-nosed Pit Viper (Hypnale hypnale) Venom following intravenous and intramuscular injections of the venom into rabbits, Toxicon 79: 37-44 (ISI-Indexed)

Yap, M.K.K., Tan, N.H., Sim, S.M., Fung, S.Y. and Tan, C.H. (2014). Pharmacokinetics of Naja sumatrana (Equatorial spitting cobra) venom and its major toxins in experimentally envenomed rabbits. Plos Neglected Tropical Diseases, 8, e2890 (ISI-Indexed)

Michelle KK Yap, SY Fung, KY Tan, NH Tan (2014) Proteomic characterization of venom of the medically important Southeast Asian Naja sumatrana (Equatorial spitting cobra), Acta Tropica 133:15-25 (ISI-Indexed)

Hui-Yeng Yeannie Yap, Azlina Abdul Aziz, Shin-Yee Fung, Szu-Ting Ng, Chon-Seng Tan, Nget-Hong Tan (2014. Energy and Nutritional Composition of Tiger Milk Mushroom (Lignosus tigris C.S. Tan) Sclerotia and the Antioxidant Activity of Its Extracts, International Journal of Medical Sciences 11(6):602-607 (ISI-Indexed)

Mui Li Lee, Shin Yee Fung, Ivy Chung, Jayalakshimi Pailoor, Swee Hung Cheah, Nget Hong Tan (2014) King Cobra (Ophiophagus hannah) Venom L-Amino Acid Oxidase Induces Apoptosis in 1 PC-3 Cells and Suppresses PC-3 Solid Tumor Growth in a Tumor Xenograft Mouse Model, International Journal of Medical Sciences,11(6) 593-601 (ISI-Indexed)

Poh Kuan Leong, Choo Hock Tan, Si Mui Sim, Shin Yee Fung, Khomvilai Sumana, Visith Sitprija, Nget Hong Tan (2014). Cross Neutralization of Common Southeast Asian Viperid Venoms by a Thai Polyvalent Snake Antivenom (Hemato Polyvalent Snake Antivenom), Acta Tropica 132:7-14 (ISI-Indexed)

Hui-Yeng Y Yap, Yit-Heng Chooi, Mohd Firdaus-Raih, Shin- Yee Fung, Szu-Ting Ng, Chon-Seng Tan, Nget- Hong Tan (2014) The genome of the Tiger Milk mushroom, Lignosus rhinocerotis, provides insights into the genetic basis of its medicinal properties, BMC Genomics 15:635 (ISI-Indexed)

Mui Li Lee, Ivy Chung, Shin Yee Fung, M.S. Kanthimathi and Nget Hong Tan (2013) Antiproliferative activity of king cobra (Ophiophagus hannah) venom L-amino acid oxidase, Basic & Clinical Pharmacology & Toxicology 114 (4): 336-343 (ISI-Indexed)

2013

Esther LH Tang, Jayakumar Rajarajeswaran, Shin Yee Fung and M S Kanthimathi (2013) Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migration. BMC Complementary and Alternative Medicine 2013, 13:347 doi:10.1186/1472-6882-13-347. (ISI-Indexed)

Yeannie HY Yap,NgetHong Tan,ShinYee Fung,Azlina A Aziz,ChonSeng Tan and SzuTing Ng (2013) Nutrient composition, antioxidant properties, and anti- proliferative activity of wild type and cultivated strain of Lignosus rhinocerus Cooke (Tiger milk mushroom) sclerotium, Journal of the Science of Food and Agriculture 93(12):2945-2952 (ISI-Indexed)

Shin Yee Fung & Nget Hong Tan (2013). Isolation, characterization and antigenic cross-reactivities of the major hemorrhagin from Cryptelytrops purpureomaculatus venom. Indian Journal of Experimental Biology, vol 51, pp.1063-1069 (ISI-Indexed)

Sook Shien Lee, Francis Kanyan Enchang, Nget Hong Tan, Shin Yee Fung, Jayalakshmi Pailoor (2013) Preclinical toxicological evaluations of the sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk mushroom, Journal of Ethnopharmacology,147 (157-163) (ISI-Indexed)

Michelle Khai Khun Yap, Nget Hong Tan, Si Mui Sim, Shin Yee Fung (2013)Toxicokinetics of Naja sputatrix (Javan spitting cobra) venom following intramuscular and intravenous administration of venom into rabbits, Toxicon 68, 18-23 (ISI-Indexed)

Si Mui Sim, Kamelia Saremi, Nget Hong Tan, Shin Yee Fung (2013) Pharmacokinetics of Cryptelytrops purpureomaculatus (mangrove pit viper) venom following intravenous and intramuscular injections in rabbits, International Immunopharmacology 17:997-1001 (ISI-Indexed)

2012

Tan, N.H. Fung, S.Y. and Yeannie Yap H.Y. (2012). Isolation and characterization of the thrombin-like enzyme from Cryptelytrops albolabris (white-lipped tree viper) venom. Comp. Biochem. Physiol. B. 161, 79-85. (ISI-Indexed)

Choo Hock Tan,Nget Hong Tan, Si Mui Sim, Shin Yee Fung, Pailoor Jayalashmi, Christeine Ariaratnam Gnanathasan. 2012. Nephrotoxicity of hump-nosed pit viper (Hypnale hypnale) venom in mice is preventable by the paraspecific Hemato polyvalent antivenom (HPA). Toxicon, 60:1259-1262 (ISI-Indexed)

Poh Kuan Leong, Si Mui Sim, Shin Yee Fung, Khomvilai Sumana, Visith Sitprija, Nget Hong Tan (2012), Cross Neutralization of Afro-Asian Cobra and Asian Krait Venoms by a Thai Polyvalent Snake Antivenom (Neuro Polyvalent Snake Antivenom), PLoS Neglected Tropical Diseases, vol 6:6, e1672 (ISI-Indexed)

Leong, P.K., Tan, N.H., Fung, S.Y. and Sim, S.M. (2012). Cross neutralization of Southeast Asian cobra and krait venoms by Indian polyvalent antivenoms. Trans Royal Soc Tropical Med. 106 , 731-737 (ISI- Cited Publication) (ISI-Indexed)

Shin Yee Fung, Nget Hong Tan, Si Mui Sim & John Chinyere Aguiyi 2011. Effects of Mucuna pruriens seed extract pretreatment on the responses of spontaneously beating rat atria and aortic ring to Naja sputatrix (Javan spitting cobra) venom. Evidence-Based Complementary and Alternative Medicine , Volume 2012, Article ID 486390, 6 pages (ISI-Indexed)

Choo Hock Tan, Nget Hong Tan, Si Mui Sim, Shin Yee Fung, Christeine Ariaranee Gnanathasan; 2012. Immunological Properties of Hypnale hypnale (hump-nosed pit viper)venom: Antibody production with diagnostic and therapeutic potentials, Acta Tropica, Volume 122, Issue 3, June 2012, Pages 267¿275 (ISI-Indexed)

Lee, M.L., Tan,N.H., Fung, S.Y., Tan, C.S. and Ng, S.T. (2012) The anti-proliferative activity of sclerotia of Lignosus rhinocerus (tiger milk mushroom). Evidence- Based Complementary and Alternative Medicine Volume 2012 (2012), Article ID 697603, 5 pages doi:10.1155/2012/697603 (ISI-Indexed)

2011

Lee, M.L., Tan, N.H., Fung, S.Y. and Shamala, D.S. (2011). Antibacterial action of a heat-stable form of L-amino acid oxidase isolated from king cobra (Ophiophagus hannah) venom. Comp. Biochem. Physiology, C. 153, 237-242 (ISI-Indexed)

S.S. Lee, N.H. Tan, S.Y. Fung, J. Pailoor, S.M. Sim (2011) Evaluation of the sub-acute toxicity of the sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk mushroom, Journal of Ethnopharmacology , 138:192-200 (ISI-Indexed)

CH Tan, PK Leong, SY Fung, SM Sim, G Ponnudurai, C Ariaratnam, S Khomvilai, V Sitprija, NH Tan 2011. Cross neutralization of Hypnale hypnale (hump-nosed pit viper) venom by polyvalent and monovalent Malayan pit viper antivenoms in vitro and in a rodent model, Acta Tropica, 117, 119-124 (ISI-Indexed)

SY Fung, NH Tan, SM Sim, Marinello E, Guerranti R, Aguiyi JC (2011), Mucuna pruriens seed extract pretreatment protects against the cardiorespiratory and neuromuscular depression effects of Naja sputatrix venom in rats, IJEB, Vol 49, pp254-259 (ISI-Indexed)

Yap, Michelle KK, Tan, N.H. and Fung, S.Y.(2011) Biochemical and toxinological characterization of Naja sumatrana (Equatorial spitting cobra) venom, J Venom Anim Toxins incl Trop Dis 17:4, 451-459 (ISI-Indexed)

Tan, C.H., Fung, S.Y. Ponnudurai, G., Ariaratnam, C.A., Sim, S.M., Tan, N.H. (2011). Enzymatic and toxinological activities of Hypnale hypnale (hump- nosed pit viper) venom and its fractionation by ion exchange high performance liquid chromatography. J. Venom. Anim. Toxins Incl. Trop.Med. 17:4, 473-485 (ISI-Indexed)

2010

S.Y. Fung, N.H. Tan, and S.M. Sim (2010), Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats, Tropical Biomedicine, 27(3):366-372 (ISI-Indexed)

Tan, N.H., Fung, S.Y. and Ponnudurai, G. (2010). Enzymatic and immunological properties of Bungarus flaviceps (red-headed krait) venom. J. Venom. Anim. Toxins Incl. Trop.Med. 16(1), 147-154 (ISI-Indexed)

2009

Tan NH, Ponnudurai G, Fung SY, 2009. Serum kinetics of Calloselasma rhodostoma (Malayan Pit Viper) venom components in a rabbit, J. Venom. Anim.Toxins uncl. Trop. Dis.15(2), 340-346 (ISI-Indexed)

Nget-Hong, Tan; Si-Mui, Sim; Shin Yee, Fung; Enrico Marinello; Roberto Guerranti; John C. Aguiyi 2009. The protective effect of Mucuna pruriens seeds against snake venom poisoning ,Journal of Ethnopharmacology 123, 356-358 (ISI-Indexed)

S.Y.Fung, N.H.Tan, S.H.Liew, S.M.Sim, J.C.Aguiyi 2009. The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats, Trop. Biomed.26(1), 80-84 (ISI-Indexed)

2008

The protective effect of Mucuna pruriens seed against cobra venom poisoning: immunological studies (2008), Tan, N.H., Fung, S.Y., Marinello, E., Guerranti, R., Aguiyi, J., The FEBS Journal, P432 (ISI-Indexed)

Snake venom L-amino acid oxidases and their potential biomedical applications (2008), Nget-Hong, Tan and Shin-Yee, Fung, Malaysian Journal of Biochemistry and Molecular Biology, 16(1), 1-10 (Non-ISI/Non-SCOPUS)

2007

The protective effect of Mucuna pruriens seed against snake venom poisoning : Gene expression studies (2007), Tan, N.H., Fung, S.Y., Marinello, E., Guerranti, R., Jeyaseelan, K., Armugam, A., Aguiyi, J., The FEBS Journal 2745:298

2006

Effect of pretreatment with Mucuna pruriens seed extract on the pharmacological effects of Naja naja sputatrix (Malayan cobra) venom in rats, Sim, S.M., Fung, S.Y., Tan, N.H., Marinello, E., Roberto, G, Aguiyi, J.C. University of Malaya, Kuala Lumpur, Malaysia, 2University of Siena, Siena, Italy, 3 University of Jos, Jos, Nigeria. Acta Pharmacologica Sinica, s1, p326 (ISI-Indexed)

2004

Immunological Cross-reactions between Snake Venoms and anti-mucuna pruriens IgG, Marinello, E., Guerranti, R., Pagani, R., Aguiyi, J.C., Tan, N.H. and Fung S.Y., Dipartimento di Medicina Interna, Scienze Endocrino-Metaboliche e Biochimica, Department of Pharmacology, University of Jos, Jos, Nigeria and Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia European Journal of Biochemistry, 271, s1, p106 (ISI-Indexed)

2002

A Hemorrhagic Toxin from the venom of Trimeresurus purpureomaculatus Snake (Mangrove Pit Viper), S.Y. Fung and N. H. Tan, Department of Biochemistry, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia The Federation of European Biochemical Societies Journal, Volume 269, pg 99 (ISI-Indexed)



Current profession

Current professional activities type: 
Research
Teaching
Higher Education Study
Professor of Biochemistry in Department of Molecular Medicine, Faculty of Medicine Principal Investigator, Medicinal Mushroom Research Group (MMRG)

Affiliations

Malaysian Society of Biochemistry and Molecular Biology
Society of Chemical Industry
World Alliance for Breastfeeding Action (WABA)
Golden Key National Honor Society of Malaysia
OWSD 6th General Assembly certificate: download

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