Member Profile

Membership type: full
Najla Kharrat
Country of origin: Tunisia Currently in: Tunisia, Sfax General field of specialization: Other-
Degrees
Other -
Current Research Activities
Other
Cardiovascular diseases, protein cluster charge, genomics
Publications resulting from Research:
Najla Kharrat, Ines Zidi, Rania abdelhedi, Amna Ben Hassine, Ahmed Baligh Laaribi, Hamza Ben Yahia, Nouha Abdelmouleh, Leila Abid, Ahmed Rebai, Roberta Rizzo Non classical human leukocyte antigen (HLA-G, HLA-E, and HLA-F) in coronary artery disease. (In press), Human immunology (2016).
Abdelhedi R, Bouayed NA, Alfadhli S, Abid L, Rebai A, Kharrat N. Characterization of drug-metabolizing enzymes CYP2C9, CYP2C19 polymorphisms in Tunisian, Kuwaiti and Bahraini populations. J Genet. 2015, 94(4):765-70.
Zidi I, Kharrat N, Sebai R, Zidi N, Yahia HB, Bouaziz A, Rifi H, Mezlini A, Rizzo R. Pregnancy and breastfeeding: a new theory for sHLA-G in breast cancer patients? Immunol Res. 2015
Ben Halim N, Dorboz I, Kefi R, Kharrat N, Eymard-Pierre E, Nagara M, Romdhane L, Ben Alaya-Bouafif N, Rebai A, Miladi N, Boespflug-Tanguy O, Abdelhak S. Determination of arylsulfatase A pseudodeficiency allele and haplotype frequency in the Tunisian population. Neurol Sci. 2015 ; 14.
Belmabrouk S, Kharrat N, Benmarzoug R, Rebai A. Exploring proteome-wide occurrence of clusters of charged residues in eukaryotes. Proteins. 2015; 11.
Louati R, Abdelmoula NB, Trabelsi I, Abid D, Lissewski C, Kharrat N, Kamoun S, Zenker M, Rebai T. Clinical and Molecular Findings of Tunisian Patients with RASopathies. Mol Syndromol. 2014 ; 5(5):212-7
Lasram K, Ben Halim N, Hsouna S, Kefi R, Arfa I, Ghazouani W, Jamoussi H,Benrahma H, Kharrat N, Rebai A, Ben Ammar S, Bahri S, Barakat A, Abid A, Abdelhak S. Evidence for association of the E23K variant of KCNJ11 gene with type 2 diabetes in Tunisian population: population-based study and meta-analysis. Biomed Res Int. 2014;2014:265274
Bougacha-Elleuch N, Charfi N, Kharrat N, Ayadi F, Maalej A, Chabchoub G, Rebai A, Kammoun-Krichen M, Belguith-Maalej S, Abid M, Mnif M, Ayadi H. A 20 year history of clinical and genetic study of thyroid autoimmunity in a Tunisian multigenerational family: Evidence for gene interaction. Meta Gene. 2013 ;29;2:63-71.
Fourati M, Mnif M, Kharrat N, Charfi N, Kammoun M, Fendri N, Sessi S, Abid M,Rebai A, Fakhfakh F.Association between Leptin gene polymorphisms and plasma leptin level in three consanguineous families with obesity. Gene. 2013; 7.S0378-1119(13)00731-2
Rania Abdelhedi, Najla Kharrat, Nouha Abdelmoula Bouayed ,Wafa Abdelmouleh, Imen Trabelsi Sahnoun , Suad AlFadhli, Leila Abid, Lobna Laroussi and Ahmed Rebai. Polymorphisms of the NOS3 and ACE gene in southern Tunisian samples with Coronary Artery Disease and controls. Biochem Genet. 2013 Feb;51(1-2):92-100.
Najla Kharrat, Wafa Abdelmouleh, Rania Abdelhedi, AlFadhli Suad, Ahmed Rebai.The Linkage disequilibrium pattern of the ACE gene in Arabic and Asian population groups. Annals of human Bioogy. 2012 Nov-Dec;39(6):538-40.
Fourati H, Bouzid D, Abida O, Kharrat N, Mnif F, Haddouk S, Fesel C, Costa J, Ben Ayed M, Abid M, Rebai A, Penha-Gonçalves C, Masmoudi H. Non-HLA autoimmunity genetic factors contributing to Autoimmune Polyglandular Syndrome type II in Tunisian patients. Hum Immunol. 2012 ;73(7):740-6.
Fourati H, Bouzid D, Abida O, Kharrat N, Marzouk S, Fesel C, Ben Ayed M, Bahloul Z, Penha-Gonçalves C, Rebai A, Masmoudi H. Genetic factors contributing to systemic Lupus erythematosus in Tunisian Patients. Journal clinical cellular immunology.2012 ; 3(4):3-129.
Triki –Fendri S, AlFadhli S, Ayadi I, Kharrat N, Ayadi H, Rebai A.Genetic Structure in Kuwaiti Population Revealed by Y-STR Diversity. Annals of Human Biology 2010, 37(6):827-35.
AlFadhli Suad, Kharrat Najla & Rebai Ahmed. Genome Scan Meta-Analysis in Systemic Lupus Erythematosus Strong linkage with loci 6p22.3-p21.1, and 2q31.1-34. Journal of Medical Genetics and Genomics. Journal of Medical Genetics and Genomics, 2010; Vol. 2 (1).
Choura M, Frikha F, Kharrat N, Aifa S, Rebaï A. Investigating the Function of Three Non-Synonymous SNPs in EGFR Gene: Structural Modelling and Association With Breast Cancer. Protein J. 2010; 29(1):50-4.
AlFadhli Suad, AlTimimy Bader, Kharrat Najla, AlSaeed Khalid, Haider Mohamad & Rebai Ahmed. Molecular analysis of HumDN1 VNTR polymorphism of the human deoxyribonuclease I in Systemic Lupus Erythematosus. Int J Immunogenet. 2010;37(1):5-8.
Kallel I, Kharrat N, Al-Fadhly S, Rebai M, Khabir A, Boudawara TS, Rebaï A. HER2 Polymorphisms and Breast Cancer in Tunisian Women. Genet Test Mol Biomarkers. 2009, 23.
Kharrat Najla, Suad Al’Fadhli and Ahmed Rebaï. Screening and validation of dinucleotide repeats in intron1 of human EGFR gene and its paralog in Her2 gene. Journal of Receptors and Signal Transduction. 2008; 28(5): 475-83.
Kharrat Najla, Suad Al’Fadhli, Maha. Rebaï, Mohamed. Sami Aifa, Imen. Kallel, Abdelmajid. Khabir, Tahia Sellami-Boudawara & Ahmed Rebaï. Dinucleotide (AC) repeat polymorphism in intron1 of human EGFR shows ethnic specificities and no evidence for association with breast cancer. Int J Biol Markers. 2007 ; 22(4):258-64.
Suad Al’fadhli, Kharrat Najla, Bader Al-Tememy, Arti Nanda and Ahmed Rebai. Susceptible and Protective Endothelial Nitric Oxide Synthase Gene Polymorphism in Alopecia Areata in the Kuwaiti population. Autoimmunity. 2008; 41(7):522-5.
Kharrat N, Maha Rebai & Ahmed Rebai. Linkage disequilibrium in the Human genome and its exploitation. Arcs. Inst. Pasteur Tunis, 2006.
Kharrat N, I. Ayadi & A. Rebai. 2006. Sample sizes computation for association studies using case-parents design. Journal of Genetics, 85(3):187-191.
M. Rebaï, Najla. Kharrat, I. Ayadi & A. Rebaï. Haplotype structure of five SNPs within the ACE gene in the Tunisian population. Annals of Human Bioloy, 33(3):319-329. 2006.
Current profession
Current professional activities type:ResearchTeachingOthercoaching and montoring of new collegues newly recruted. Training and supervising students Build up of new collaboration and partnerships
Workshop and Conference Attended
2012 Istambul, turkey Bioinformatics Approaches for Analysis of High-throughput Biological Data2015 Saoudi arabia International Genome Medecine ConferenceAffiliations
active member in Association of the young Tunisian Researcher (ATCU)Presentation given
2013Outils de modélisation graphique de réseaux géniquesMonastir, TunisiaEvent: 11ième journées d’immunologie2011Bioinformatics in TunisiaTunisiaEvent: Detection, gestion et analyse du polymorphisme des genomes végétaux -
TWAS Awards
Jun 2015OtherResearch Grant agreement from TWAS