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Membership type: full

Violet Kayamba Kelly

Country of origin: Zambia Currently in: Zambia, Lusaka General field of specialization: Medical and Health Sciences incl Neurosciences
Early Career Fellowship
Academic Background

Degrees

2019 Doctorate Medical and Health Sciences incl Neurosciences
2012 Master Medical and Health Sciences incl Neurosciences
2006 Undergraduate Medical and Health Sciences incl Neurosciences
2003 Undergraduate Medical and Health Sciences incl Neurosciences
Research and Profession

Current Research Activities

Medical and Health Sciences incl Neurosciences

I am a medical gastroenterologist and faculty member of the University of Zambia School of Medicine. I am a founding fellow of the East, Central, and Southern African College of Physicians, current president of the Zambia College of Gastroenterology and Nutrition and I served as treasurer for the Zambia College of Physicians. I am also a member of the African Organisation for Research and Training in Cancer and one of the founding members of the recently formed African Oesophageal Cancer Consortium. My main research interests are in upper gastrointestinal cancers. As a faculty member of the University of Zambia School of Medicine, I intend to continue contributing towards improved research output from sub-Saharan Africa.


Publications resulting from Research: 


1. Kasochi C, Julius P, Mweemba I, Kayamba V. Human epidermal growth factor receptor 2 overexpression in gastric and gastroesophageal junction adenocarcinoma in patients seen at the University Teaching Hospital, Lusaka, Zambia. Afr Health Sci. 2020. In press
2. Kayamba V, Zyambo K, Mulenga C, Mwakamui S, Tembo MJ, Shibemba A, Heimburger DC, Atadzhanov M, Kelly P. Biomass Smoke Exposure Is Associated With Gastric Cancer and Probably Mediated Via Oxidative Stress and DNA Damage: A Case-Control Study. JCO Glob Oncol. 2020 Mar;6:532-541. doi: 10.1200/GO.20.00002. PMID: 32228314; PMCID: PMC7113078.
3. Kayamba V, Butt J, Waterboer T, Besa E, Choudhry N, Hamasuku A, Julius P, Heimburger DC, Atadzhanov M, Kelly P. Molecular profiling of gastric cancer in a population with high HIV prevalence reveals a shift to MLH1 loss but not the EBV subtype. Cancer Med 2020 May;9(10):3445-3454. doi: 10.1002/cam4.3001. PMID: 32207245.
4. Furch BD, Koethe JR, Kayamba V, Heimburger DC, Kelly P. Interactions of Schistosoma and HIV in sub-Saharan Africa: A systematic review. Am. Jour. of Trop. Med and Hyg, 2020; 0; (0) 1-9. doi: 10.4269/ajtmh.19-0494.
5. Kvalsund M, Kayamba V, Kelly P, Birbeck G, Mwansa-Thurman C, Sommer I Lamers Y, Gardiner J, Herrmann D. (2019). Is folate deficiency a common cause of distal symmetric polyneuropathy in Zambian clinics?. Journal of the Neurological Sciences. Nov 2019; (409) 116583. 10.1016/j.jns.2019.116583.
6. Kayamba V. Oesophageal cancer hotspots in Africa. Lancet Gastroenterol Hepatol. 2019 Nov; 4(11):818-820. doi: 10.1016/S2468-1253(19)30253-5.
7. Kayamba V, Kelly P. Delayed referral for diagnostic endoscopy is a contributing factor to late gastric cancer diagnosis in Zambia. Health Press Zambia Bull. 2019; 3(2); 14-19.
8. Shah SC, Kayamba V, Peek RM Jr, Heimburger D. Cancer Control in Low- and Middle-Income Countries: Is It Time to Consider Screening? J Glob Oncol. 2019 Mar;(5):1-8. doi: 10.1200/JGO.18.00200.
PMCID: PMC6452918.
9. Kayamba V, Shibemba A, Zyambo K, Heimburger DC, Morgan D, Kelly P. HIV related hypochlorhydria does not appear to respond to anti-retroviral therapy in Zambian adults: a case control study, The Pan African Medical Journal. 2018;31:128. doi:10.11604/pamj.2018.31.128.11850. PMCID: PMC6462371
10. Kayamba V, Zyambo K, Kelly P. Presence of blood in gastric juice: A sensitive marker for gastric cancer screening in a poor resource setting. PLoS One. 2018 Oct 15; 13(10):e0205185. doi: 10.1371/journal.pone.0205185. eCollection 2018. PMCID: PMC6188746.
11. Chongwe G, Michelo C, Sinkala E, Kayamba V, Nzayisenga JB, Drobniewski F, Kelly P. Mycobacterium avium lysate induces matrix metalloproteinase-1 in intestinal tissue and peripheral blood: observations from selected hospital based Zambian adults. Int J Infect Dis. 2018 Jun;71:73-81. doi: 10.1016/j.ijid.2018.03.020. PMCID: PMC5985370
12. Kayamba V, Nicholls K, Morgan C, Kelly P. A seven-year retrospective review of colonoscopy records from a single centre in Zambia. Malawi Medical Journal, Malawi Med J. 2018 Mar; 30(1): 17-21.
PMCID: PMC5974381
13. Van Loon K, Mwachiro MM, Abnet CC, Akoko L, Assefa M, Burgert SL, Chasimpha S, Dzamalala C, Fleischer DE, Gopal S, Iyer PG, Kaimila B, Kayamba V, Kelly P, Leon ME, Mathew CG, Menya D, Middleton D, Mlombe Y, Mmbaga BT, Mmbaga E, Mulima G, Murphy G, Mushi B, Mwanga A, Mwasamwaja A, Parker MI, Pritchett N, Schüz J, Topazian MD, White RE, McCormack V, Dawsey SM. The African Esophageal Cancer Consortium: A Call to Action. Journal of Global Oncology 2018: 4, 1-9, doi: 10.1200/JGO.17.00163. PMCID: PMC6223465
14. Sinkala E, Zyambo K, Besa E, Kaonga P, Nsokolo B, Kayamba V, Vinikoor M, Zulu R, Bwalya M, Foster GR, Kelly P. Rifaximin Reduces Markers of Inflammation and Bacterial 16S rRNA in Zambian Adults with Hepatosplenic Schistosomiasis: A Randomized Control Trial. Am J Trop Med Hyg. 2018 Apr;98(4):1152-1158. doi: 10.4269/ajtmh.17-0637. PMCID: PMC5928821.
15. Kayamba V, Shibemba A, Zyambo K, Heimburger DC, Morgan DR, Kelly P. High prevalence of gastric intestinal metaplasia detected by confocal laser endomicroscopy in Zambian adults. PLoS One. 2017; 12(9):e0184272. doi: 10.1371/journal.pone.0184272. PMCID: PMC5590914.
16. Kayamba V, Heimburger DC, Morgan DR, Atadzhanov M, Kelly P. Exposure to biomass smoke as a risk factor for oesophageal and gastric cancer in low-income populations: A systematic review. Malawi Medical Journal 2017; 29(2): 212-217. PMCID: PMC5610298.
17. Asombang AW, Kayamba V, Lisulo MM, Trinkaus K, Mudenda V, Sinkala E, Mwanamakondo S, Banda T, Soko R, Kelly P. Esophageal squamous cell cancer in a highly endemic region. World J Gastroenterol 2016; 22(9): 2811-2817. doi: 10.3748/wjg.v22.i9.2811. PMCID: PMC4778003
18. Kayamba V, Monze M, Asombang AW, Zyambo K, Kelly P. Serological response to Epstein-Barr virus early antigen is associated with gastric cancer and human immunodeficiency virus infection in Zambian adults: a case-control study. Pan African Medical Journal. 2016; 23:45. doi: 10.11604/pamj.2016.23.45.8503. PMCID: PMC4862785.
19. Kayamba V, Sinkala E, Mwanamakondo S, Soko R, Kawimbe B, Amadi B, Zulu I, Nzaisenga JB, Banda T, Mumbwe C, Phiri E, Munkonge P, Kelly P. Trends in upper gastrointestinal diagnosis over four decades in Lusaka, Zambia: a retrospective analysis of endoscopic findings. BMC Gastroenterol. 2015; 15(1): 127. doi: 10.1186/s12876-015-0353-8. PMCID: PMC4596361
20. Thakur KT, Matteo K, Hachaambwa L, Kayamba V, Mallewa M, Mallewa J, Nwazor E, Lawal T, Bala CM, Atadzhanov M, Boulware D, Birbeck GL, Siddiqi OK. Lumbar Puncture Refusal in sub-Saharan Africa: a Call for Further Understanding and Intervention. Neurology. 2015; 84(19): 1988-90. doi: 10.1212/WNL.0000000000001561. PMCID: PMC4433455.
21. Kayamba V, Bateman AC, Asombang AW, Shibemba A, Zyambo K, Banda T, Soko R, Kelly P. HIV infection and domestic smoke exposure, but not human papillomavirus, are risk factors for esophageal squamous cell carcinoma in Zambia: a case-control study. Cancer Med. 2015; 4: 588-95. doi: 10.1002/cam4.434 . PMCID: PMC4402073.
22. Asombang AW, Kayamba V, Turner-Moss E, Banda L, Trinkaus K, Colditz G, Mudenda V, Zulu R, Sinkala E, Kelly P. Gastric malignancy survival in Zambia, Southern Africa: A two year follow up study, Medical Journal of Zambia, 2014; 41(1): 13-18.
23. Kayamba V, Chomba M, Kelly P. Short-term micronutrient-antioxidant supplementation has no impact on a serological marker of gastric atrophy in Zambian adults: retrospective analysis of a randomised controlled trial. BMC Gastroenterol. 2014; 14: 52. doi: 10.1186/1471-230X-14-52. PMCID: PMC3987176.
24. Lisulo MM, Kapulu MC, Banda R, Sinkala E, Kayamba V, Sianongo S, Kelly P. Adjuvant potential of low dose all-trans retinoic acid during oral typhoid vaccination in Zambian men. Clin Exp Immunol. 2014; 175(3): 468-75. doi: 10.1111/cei.12238. PMCID: PMC3927907
25. Kayamba V, Asombang AW, Mudenda V, Lisulo MM, Sinkala E, Mwanamakondo S, Mweemba I, Kelly P. Gastric adenocarcinoma in Zambia: a case-control study of HIV, lifestyle risk factors, and biomarkers of pathogenesis. S Afr Med J 2013; 103: 255-259. doi: 10.7196/ samj.6159. PMCID: PMC3815678
26. Asombang AW, Kayamba V, Mwanza-Lisulo M, Colditz G, Mudenda V, Yarasheki K, Chott R, Rubin D, Gyawali CP, Sinkala E, Mwanamakondo S, Anderson-Spearie C, Kelly P. Gastric cancer in Zambian adults: a prospective case-control study assessing dietary intake and antioxidant status using isoprostane excretion. Am J Clin Nutr 2013; 97: 1029- 1035. doi: 10.3945/ajcn.112.051284. PMCID: PMC3628375



Current profession

Current professional activities type: 
Research
Teaching
Other
I am involved in teaching, medical research and clinical work.

Workshop and Conference Attended

2019 San Diego, USA Digestive Diseases Week, American Gastroenterological Association
2018 Washington DC, USA Digestive Diseases Week, American Gastroenterological Association
2017 Kigali, Rwanda African Organisation for Research and Training in Cancer, International cancer Conference
2016 San Diego, California, USA Digestive Diseases Week, American Gastroenterological Association
2016 Nairobi, Kenya WGO Nairobi Training Center Inauguration & Training Workshop
2016 San Francisco, California, USA SPIE. BIOS Expo and Photonics West
2015 Washington DC, USA Digestive Diseases Week, American Gastroenterological Association
2013 Granada, Spain IUNS 20th International Congress of Nutrition
2013 Glasgow, Scotland British Society of Gastroenterology
2012 Amsterdam, Netherlands United European Gastroenterology Week
2012 Marseille, France International Symposium HIV and Emerging Infectious Diseases
2011 Stockholm, Sweden United European Gastroenterology Week

Presentation given

2018
Case-control study on gastric cancer risk factors in Zambia
Rockville, USA
Event: Stomach Cancer Pooling Project
2019
Oesophageal cancer epidemic: An African perspective
London, UK
Event: Cancer Research UK; Oesophageal cancer symposium
Fellowship with OWSD

Fellowship with OWSD

Fellowship with OWSD

Fellowship awarded

Early Career Fellowship awarded 2020

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