Member Profile
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Membership type: full
Zeinab Elshahid
Country of origin: Egypt Currently in: Egypt, Cairo General field of specialization: Medical and Health Sciences incl Neurosciences-
Degrees
2019 Doctorate Medical and Health Sciences incl Neurosciences -
Current Research Activities
Medical and Health Sciences incl Neurosciences
The search for new drug candidates from natural and synthetic resources with variable biological activities as antitumor, anti-inflammatory, wound healing, antimicrobial, and antioxidant, cell culture, 2D, and 3D models, Gene expression analysis and DNA fragmentation assay, and flow cytometry (cell cycle analysis), different in-vivo models on mice and rats.
Publications resulting from Research:
1. Boshta, N.M., Temirak, A., El-Shahid, Z.A., Shafiq, Z., Soliman, A.A.F.Design, synthesis, molecular docking and biological evaluation of 1,3,5-trisubstituted-1H-pyrazole derivatives as anticancer agents with cell cycle arrest, ERK and RIPK3- kinase activities. Bioorganic Chemistry, 2024, 143, 107058.
2. Elshahid, Z.A.; Salama, A.A. and Gouhar,S.A. Naringin attenuates D-galactose-induced brain aging via regulation of oxidative stress markers TNF-α, NF-κβ and modulation of the neurotrophic markers PGC1-α , NT-3 AGEs, and GFAP in vivo. Egyp.J.Chem,(2024),67(2)2,,1-15, http://doi.org/10.21608/EJCHEM.2023.212559.8002.
3. Elshahid, Z.A., Salama, A. & Gouhar, S.A. Assessment of the synergistic anti-inflammatory effect of naringin/sulindac for the treatment of osteoarthritis: in vitro and in vivo. ADV TRADIT MED (ADTM) (2023). https://doi.org/10.1007/s13596-023-00692-4.
4. El-Sawy, E.R.; El-Shahid, Z.A.; Soliman, A.A.F.; Nassrallah, A.; Abdelwahab, A.B.; Kirsch, G.; Abdelmegeed, H. Synthetic Analogs of Marine Alkaloid Aplysinopsin Suppress Anti-Apoptotic Protein BCL2 in Prostate Cancer. Molecules 2023, 28, 109. https://doi.org/ 10.3390/molecules28010109.
5. Mahmoud, K., Mohammed, A., Salem, D., Ibrahim, K., Shawky, M., Osama, M., Rageh, M., Tarek, R., El Shahed, Z.A. (2022). 'Cytotoxic, Genotoxic and pro-apoptotic effect of some medicinal plants on the expression of colon cancer-related genes (P53 & Bcl2) in the colorectal cell line and syngenic animal cancer model', Egyptian Journal of Chemistry, 65(11), pp. -. doi: 10.21608/ejchem.2022.138368.6087.
6. Elhallouty, S., Rashad, A., Abd elrhman, E., Elkaramany, H., Ibrahim, M., Salem, N., Adeeb, R., Ibrahim, Y. El Shahed, ZA (2022). 'Effect of Ginkgo biloba leaf extract in combination with vitamin C, E and D on Aluminum Chloride induced Alzheimer in rats.', Egyptian Journal of Chemistry,65 (13), pp. -. doi: 10.21608/ejchem.2022.133257.5889.
7. Eid, M.M., Ismail, A.M., Elshahid, Z.A. Abd Elzaher FH. Mahmoud K. El-Manawaty M. (2022). Plasmonic Superparamagnetic SPION@Ag@chitosan Core-shell: Uptake and Nitric Oxide Inhibition by Colorectal Cell Lines. J Inorg Organomet Polym . https://doi.org/10.1007/s10904-021-02213-9.
8. Zeinab A. EL-Shahid, Faten K. Abd EL-Hady, Walid Fayad, Mohamed S. Abdel-Aziz, Eman M. Abd EL-Azeem & Emad K. Ahmed (2021) Antimicrobial, Cytotoxic, and α-Glucosidase Inhibitory Potentials Using the One Strain Many Compounds Technique for Red Sea Soft Corals Associated Fungi’ Secondary Metabolites and Chemical Composition Correlations, Journal of Biologically Active Products from Nature, 11:5-6, 467-489, DOI: 10.1080/22311866.2021.1978862.
9. Shaimaa A. Gouhar & Zeinab A. Elshahid (2021): Molecular docking and simulation studies of synthetic protease inhibitors against COVID-19: a computational study,Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2021.1997822.
10. Hussein RA., Afifi AH., Soliman A.A.F., El Shahid Z.A., Zoheir KM.A., Mahmoud K.M. Neuroprotective activity of Ulmus pumila L. in Alzheimer's disease in rats; role of neurotrophic factors, Heliyon , 2020, (6) e05678.
11. EL-Shahid ZA, Ahmed EK, Abd EL-Azeem EM, Abdel-Aziz MS, Abd EL-Hady FK. Antioxidant Activity Index of Sponge and Soft Corals - Associated Fungi of the Red Sea, Egypt, Middle East J. Appl. Sci., (2018) 8(3): 1035-1045.
12. Faten K. Abd El-Hady,Walid Fayad,Carmine Iodice, Zeinab A. El-Shahid, Mohamed S. Abdel-Aziz,Egle Crudele & Giuseppina Tommonaro Investigating on the Correlation Between Some Biological Activities of Marine Sponge-Associated Bacteria Extracts and Isolated Diketopiperazines, Current Microbiology volume 74, pages6–13 (2017).
13. Salah, N. M., Souleman, A. M., Shaker, K. H., El Hawary, S., El-Shahid, Z. A., & Abd El-Hady, F. K. Acetylcholinesterase, Alpha-Glucosidase and Tyrosinase Inhibitors from Egyptian Propolis, International Journal of Pharmacognosy and Phytochemical Research 2017; 9(4); 528-536 ISSN: 0975-4873, DOI number: 10.25258/phyto.v9i2.8126.
14. Abd El-Hady, F.K., Abdel-Aziz, M.S., Souleman, A.M.A., El-Shahid, Z.A., Shaker, K.H. Enhancement of acetylcholinesterase inhibitory activity for the soft coral associated fungus aspergillus unguis SPMD-EGY by media composition, International Journal of Pharmaceutical Sciences Review and Research, 2016, 41(2), pp. 349–357, 64
15. Abd El-Hady, F.K., Abdel-Aziz, M.S., Shaker, K.H., El-Shahid, Z.A. Effect of media composition on potentiality improving -glucosidase inhibitory activity for the soft coral associated fungus Aspergillus unguis SPMD-EGY, International Journal of Pharmaceutical Sciences Review and Research, 2016, 38(2), pp. 173–180, 33
16. Abd El-Hady, F.K., Souleman, A.M.A., El Hawary, S., Salah, N.M., El-Shahid, Z.A. GC/MS and HPLC analysis of alpha-glucosidase inhibitor′s sub-fractions from Egyptian propolis, International Journal of Pharmaceutical Sciences Review and Research, 2016, 38(1), pp. 120–129, 21
17. Abd El-Hady, F.K., Abdel-Aziz, M.S., Souleman, A.M.A., El-Shahid, Z.A., Shaker, K.H. Potentiality of improving or suppressing tyrosinase inhibitory activity by media composition for the marine fungus Aspergillus unguis SPMD-EGY, Der Pharma Chemica, 2016, 8(19), pp. 458–465
18. Abd El-Hady, F.K., Souleman, A.M., Ibrahim, I.G., Abdel-Aziz, M.S., El-Shahid, Z.A., Ali, E.A. and Elsarrag, M.S., Cytotoxic, anti-acetylcholinesterase, antioxidant and antimicrobial activities of Sudanese propolis with correlation to its GC/MS and HPLC analysis. Pharm Lett, 2016., 8(19), pp.339-350.
19. Abd El-Hady, F.K., Souleman, A.M.A., Hawary, S.E., Salah, N.M., El-Shahid, Z.A. Egyptian propolis bioassay guided fractionation and GC/MS, HPLC analysis of highly anti-acetylcholinesterase sub-fractions,International Journal of Pharmaceutical Sciences Review and Research, 2015, 35(1), pp. 53–62, 11.
20. El-Hady, F.K.A., Souleman, A.M.A., El-Shahid, Z.A. Antiacetylcholinesterase and cytotoxic activities of Egyptian propolis with correlation to its GC/MS and HPLC Analysis, International Journal of Pharmaceutical Sciences Review and Research, 2015, 34(2), pp. 32–42.
21. Abd El-Hady, F.K., Abdel-Aziz, M.S., Shaker, K.H., El-Shahid, Z.A., Ibrahim, L.S. Antioxidant, Acetylcholinesterase and α-glucosidase potentials of metabolites from the marine fungus Aspergillus unguis RSPG_204 associated with the sponge (Agelas sp.) International Journal of Pharmaceutical Sciences Review and Research, 2015, 30(1), pp. 272–278, 48.
22. Abd El-Hady, F.K., Abdel-Aziz, M.S., Abdou, A.M., ...Ibrahim, L.S., El-Shahid, Z.A. In-vitro anti-diabetic and cytotoxic effect of the coral derived fungus (Emericella unguis 8429) on human colon, liver, breast and cervical carcinoma cell lines,International Journal of Pharmaceutical Sciences Review and Research, 2014, 27(2), pp. 296–301, 49.
23. Abd El-Hady, F.K., Abdel-Aziz, M.S., Shaker, K.H., El-Shahid, Z.A. Tyrosinase, acetylcholinesterase inhibitory potential, antioxidant and antimicrobial activities of Sponge derived fungi with correlation to their GC/MS analysis. International Journal of Pharmaceutical Sciences Review and Research, 2014, 26(2), pp. 338–345.
24. Abd El-Hady, F.K., El-Shahid, Z.A., Influence of some culinary plants on the suppression of human low density lipoprotein (LDL) peroxidation (In-vitro).International Journal of Pharmaceutical Sciences Review and Research, 2014, 26(1), pp. 209–215, 36.
25. Abd El-Hady, F.K., Abdel-Aziz, M.S., Shaker, K.H., El-Shahid, Z.A., Coral-derived fungi inhibit acetylcholinesterase, superoxide anion radical, and microbial activities,International Journal of Pharmaceutical Sciences Review and Research, 2014, 26(1), pp. 301–308, 51.
26. FK Abd El-Hady, AG Hegazi, ESM Mahdy, WG Shousha, ZA El-Shahid, Inhibitory effect of some local medicinal plants on in-vitro oxidative modification of low-density lipoprotein, Egyptian Pharmaceutical Journal 11 (1), 38.
Current profession
Current professional activities type:ResearchTeaching